1. Enable multicast routing. Various names for this, including DVMRP, IP multicast routing, PIM Dense mode (Cisco term). Enabling DVMRP will allow NBX multicast traffic to be propagated over all WAN connections to remote sites, for both remote IP phones, or other NBX sites using VTL's. Without this feature enabled, the symptom of a remote IP phone would be no ability to conference, receive pages, no BLF lamp status for mapped lines, and no date/time synchronization with the NCP.
2. Set MTU to 1500. Router MTU determines the max size of each packet before the router will fragment the packet to smaller packets. NBX devices will NOT re-assemble audio packets that have been fragmented over a WAN link, thereby resulting in NO AUDIO heard. This is seen most where phone-to-phone calls over the WAN link are OK, but no audio is heard when connected to voicemail or an auto attendant menu over the WAN link. NBX hard disk audio (aa menus, voicemail system audio) has a very large packet size, that if fragmented by ANY router, will mean it will not be played back by the receiving NBX device.
NOTE for Frame Relay and Cisco Routers, affecting Conference Audio Quality only: the command is frame-relay broadcast-queue and must be set to allow 50 pps conference audio for each simultaneous device in a conference. By default, some Cisco routers are set to only 30 pps, not even enough for ONE conference call audio stream to pass
Obviously it depends on each particular network, so this is a guideline.